Working with 2FA-enabled mail (app password not possible)

[Chris Coutinho]

Hi,

My company recently made our Office365 mail service 2FA-enabled by
default and disallowed app-specific passwords. Before this, I used
Offlineimap to download my mail and index/search it using Notmuch. Now
that that's no longer possible, I'm looking to the community for
options.

What do you use for syncing your mail to your local system(s) and
utilizing the power of Notmuch?

Thanks in advance,
Chris