Dreaming of tag-based e-mailing

[Fernando H. F. Botelho]

Hi everyone,

I use F123, which is an Ubuntu-based distribution developed for use by 
the blind. I have been researching SugarCRM and other applications 
looking for tag-based mailing without success and when I heard of Mutt 
and NotMuch I became hopeful again.

Please tell me if this would be possible with NotMuch + Mutt or 
something else:

1. I tag incoming messages with any number of arbitrary tags, and these 
get assigned not just to that specific e-mail message, but also to the 
contact (i.e. email address) behind it.
2. I decide I have a message to send to every person that has tag A, B, 
D, F, and Z, and I select those and the e-mail client allows me to 
e-mail my message to every contact that has all of those tags.

I assume there is no e-mail client that is able to do this today, is 
this correct?

Could NotMuch do this in combination with Mutt on Gnome Terminal or 
Thunderbird on Gnome?

I am not a developer but I might be able to get volunteer help if I know 
what are the pieces that are most likely to work out into a nice looking 
puzzle. By that I mean, that I need to know if I should ask for help 
from someone that knows C, Python, PHP, or something else, or if that 
someone has to be a big Mutt fan, or SugarCRM, or Thunderbird, etc.

I am also trying to find a solution that would run on Gnome or the Gnome 
Terminal as KDE is not accessible to the Orca screen reader right now.

Thanks,

Fernando